HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 2-(oxazol-2-yl)propan-2-ylcarbamate → 1-(4,5-Dihydro-oxazol-2-yl)-1-methyl-ethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 2-(oxazol-2-yl)propan-2-ylcarbamate | HCID 71087227 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(4,5-Dihydro-oxazol-2-yl)-1-methyl-ethylamine | HCID 86674752 | 33% |
Reaction Steps
A mixture of benzyl 2-(oxazol-2-yl)propan-2-ylcarbamate (Example 8 d, 0.63 g) and palladium on carbon (10% w/w, 0.06 g) in ethanol (20 mL) was charged with hydrogen balloon and stirred at room temperature for 2 h. TLC showed the reaction was complete; it was filtered and concentrated to give the product as yellow oil (0.1 g, 33%); MS (EI): m/e=129.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321727B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-4957150964464481bfe9f59ce257e520 |
| Source note | uspto-grants-2016_04 |