6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid → 6-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid [1-(4,5-dihydro-oxazol-2-yl)-1-methyl-ethyl]-amide

HRID 632069Notes

Reaction equation

HRID 632069 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:3][CH2:2]1.[O:20]1[CH2:24][CH2:23][N:22]=[C:21]1[C:25]([NH2:28])([CH3:27])[CH3:26]>>[O:20]1[CH2:24][CH2:23][N:22]=[C:21]1[C:25]([NH:28][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([CH3:27])[CH3:26]

Participants

3

Reactant 2

HCID 710877336-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acidHCID 866747521-(4,5-Dihydro-oxazol-2-yl)-1-methyl-ethylamine

Product 1

HCID 710936886-Cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid [1-(4,5-dihydro-oxazol-2-yl)-1-methyl-ethyl]-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-pyrrolidin-1-yl-pyridine-2-carboxylic acid (Example 14 a) and 1-(4,5-dihydro-oxazol-2-yl)-1-methyl-ethylamine as starting materials, MS (EI): m/e=373.2 [M+H]+.

Sources & evidence

ORD record
ord-122fd7f286934277a10e712e2f002713
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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