6-(3-Chlorophenyl)-5-methoxy-pyridine-2-carboxylic acid → 6-(3-Chloro-phenyl)-5-methoxy-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

HRID 632098Notes

Reaction equation

HRID 632098 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[O:17][CH3:18])[CH:5]=[CH:6][CH:7]=1.[NH2:19][C:20]([CH2:27][CH3:28])([CH2:25][CH3:26])[C:21]([NH:23][CH3:24])=[O:22]>>[CH2:25]([C:20]([NH:19][C:14]([C:12]1[CH:11]=[CH:10][C:9]([O:17][CH3:18])=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([C:21](=[O:22])[NH:23][CH3:24])[CH2:27][CH3:28])[CH3:26]

Participants

3

Reactant 2

HCID 710872506-(3-Chlorophenyl)-5-methoxy-pyridine-2-carboxylic acidHCID 798103702-Amino-2-ethyl-N-methyl-butyramide

Product 1

HCID 710935016-(3-Chloro-phenyl)-5-methoxy-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-methoxy-pyridine-2-carboxylic acid and 2-amino-2-ethyl-N-methyl-butyramide (Example 70 b) as starting materials, MS (EI): m/e=390.2 [M+H]+.

Sources & evidence

ORD record
ord-2232ea49d63c44bc9128a6d53cfa2955
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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