Methyl 2-aminocyclohexane-1-carboxylate → 2-[(6-Cyclohexyl-pyridine-2-carbonyl)-amino]-cyclohexanecarboxylic acid methyl ester
Reaction equation
[CH:1]1([C:7]2[N:12]=[C:11]([C:13]([OH:15])=O)[CH:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[C:23]([O:25][CH3:26])=[O:24]>>[CH3:26][O:25][C:23]([CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH:17]1[NH:16][C:13]([C:11]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[N:12]=1)=[O:15])=[O:24]Participants
3
Procedure
The title compound was synthesized in analogy to Example 1, using 6-cyclohexyl-pyridine-2-carboxylic acid (Example 7 b) and methyl 2-aminocyclohexane-1-carboxylate (CAN 40015-88-1) as starting materials, MS (EI): m/e=345.2 [M+H]+.
Sources & evidence
- ORD record
- ord-68f8fc6383004036a47c722a1fff94f7
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321727B2
Reaction notes
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