6-Cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carboxylic acid → HCID 71105588, compound

HRID 632111Notes

Reaction equation

HRID 632111 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[CH:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[CH2:3][CH2:2]1.[CH3:21][C:22]([CH3:29])([C:24]1[O:25][CH:26]=[CH:27][N:28]=1)[NH2:23]>>[CH3:21][C:22]([NH:23][C:12]([C:10]1[CH:9]=[CH:8][C:7]([CH:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([C:24]1[O:25][CH:26]=[CH:27][N:28]=1)[CH3:29]

Participants

3

Reactant 2

HCID 710874016-Cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carboxylic acidHCID 82418817alpha,alpha-Dimethyl-2-oxazolemethanamine

Product 1

HCID 71105588HCID 71105588, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carboxylic acid (Example 9 f) and α,α-dimethyl-2-oxazolemethanamine (CAN 1211519-76-4) as starting materials, MS (EI): m/e=386.2 [M+H]+.

Sources & evidence

ORD record
ord-0c7fb32c6db345569fa09becc8960b4c
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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