5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide

HRID 632119Notes

Reaction equation

HRID 632119 reaction equation
C1(C2C=CC(C(O)=O)=NC=2OCC2CC2)CC1.[CH:18]1([CH2:21][C@H:22]([NH:28][C:29]([C:31]2[CH:36]=[CH:35][C:34]([CH:37]3CCO[CH2:39][CH2:38]3)=[C:33]([O:43][CH2:44][CH:45]3[CH2:47][CH2:46]3)[N:32]=2)=[O:30])[C:23]2[S:24][CH:25]=[CH:26][N:27]=2)[CH2:20][CH2:19]1>>[CH:18]1([CH2:21][C@H:22]([NH:28][C:29]([C:31]2[CH:36]=[CH:35][C:34]([CH:37]3[CH2:39][CH2:38]3)=[C:33]([O:43][CH2:44][CH:45]3[CH2:47][CH2:46]3)[N:32]=2)=[O:30])[C:23]2[S:24][CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 711055706-Cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide

Product 1

HCID 711055915-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and (S)-2-cyclopropyl-1-thiazol-2-yl-ethylamine (Example 59 b) as starting materials, MS (LC/MS): m/e=384.3 [M+H]+.

Sources & evidence

ORD record
ord-51e914ec9f944823b2a8f0972ec583f4
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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