5-Chloro-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → 5-Chloro-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

HRID 632136Notes

Reaction equation

HRID 632136 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:13]([OH:15])=O)=[N:6][C:7]=1[O:8][CH2:9][CH:10]1[CH2:12][CH2:11]1.[NH2:16][C:17]([CH2:24][CH3:25])([CH2:22][CH3:23])[C:18]([NH:20][CH3:21])=[O:19]>>[CH2:22]([C:17]([NH:16][C:13]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[C:7]([O:8][CH2:9][CH:10]2[CH2:11][CH2:12]2)[N:6]=1)=[O:15])([C:18](=[O:19])[NH:20][CH3:21])[CH2:24][CH3:25])[CH3:23]

Participants

3

Reactant 2

HCID 710876525-Chloro-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 798103702-Amino-2-ethyl-N-methyl-butyramide

Product 1

HCID 710936125-Chloro-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-chloro-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 83 b) and 2-amino-2-ethyl-N-methyl-butyramide (Example 70 b) as starting materials, MS (EI): m/e=354.2 [M+H]+.

Sources & evidence

ORD record
ord-a4938781150a41c6ad7ac90960dcf952
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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