2-(5-Methyl-1,2,4-oxadiazol-3-yl)propan-2-amine → 6-Cyclopropylmethoxy-5-(tetrahydro-furan-2-yl)-pyridine-2-carboxylic acid [1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-amide
Reaction equation
C1(COC2N=C(C(O)=O)C=CC=2C2CCOC2)CC1.[CH:20]1([CH2:23][O:24][C:25]2[N:30]=[C:29]([C:31]([OH:33])=O)[CH:28]=[CH:27][C:26]=2[CH:34]2[CH2:38][CH2:37][CH2:36][O:35]2)[CH2:22][CH2:21]1.[CH3:39][C:40]([CH3:48])([C:42]1[N:46]=[C:45]([CH3:47])[O:44][N:43]=1)[NH2:41]>>[CH3:39][C:40]([NH:41][C:31]([C:29]1[CH:28]=[CH:27][C:26]([CH:34]2[CH2:38][CH2:37][CH2:36][O:35]2)=[C:25]([O:24][CH2:23][CH:20]2[CH2:21][CH2:22]2)[N:30]=1)=[O:33])([C:42]1[N:46]=[C:45]([CH3:47])[O:44][N:43]=1)[CH3:48]Participants
4
Reactant 3
Product 1
Procedure
The title compound was synthesized in analogy to Example 1, using the mixture of 6-(cyclopropylmethoxy)-5-(tetrahydrofuran-3-yl)-pyridine-2-carboxylic acid and 6-(cyclopropylmethoxy)-5-(tetrahydrofuran-2-yl)-pyridine-2-carboxylic acid (mixture from Example 114 d) and α,α,5-trimethyl-1,2,4-oxadiazole-3-methanamine (CAN 1153831-97-0) as starting materials, MS (EI): m/e=387.2 [M+H]+.
Sources & evidence
- ORD record
- ord-256c44f91b3242189546d0d2b41731f5
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321727B2
Reaction notes
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