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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 632163Generated: October 25, 2026

6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid → 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (1-methyl-1-oxazol-2-yl-ethyl)-amide

https://huagongshe.com/reaction/632163

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acidHCID 71087457—
Reactantalpha,alpha-Dimethyl-2-oxazolemethanamineHCID 82418817—
Product6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (1-methyl-1-oxazol-2-yl-ethyl)-amideHCID 71105609—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (Example 113 d) and α,α-dimethyl-2-oxazolemethanamine (CAN 1211519-76-4) as starting materials, MS (EI): m/e=370.1 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321727B2
Source datasetuspto-grants-2016_04
ORD IDord-2a6075b59cfd437a8d9f7b6cea20e10a
Source noteuspto-grants-2016_04