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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 632189Generated: November 1, 2026

(2R)-1-amino-2-cyclopropyl-propan-2-ol → 7,7-Dimethyl-5,6,7,8-tetrahydro-quinoline-2-carboxylic acid ((R)-2-cyclopropyl-2-hydroxy-propyl)-amide

https://huagongshe.com/reaction/632189

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2R)-1-amino-2-cyclopropyl-propan-2-olHCID 51684102—
Reactant7,7-Dimethyl-5,6,7,8-tetrahydro-quinoline-2-carboxylic acidHCID 71087472—
Product7,7-Dimethyl-5,6,7,8-tetrahydro-quinoline-2-carboxylic acid ((R)-2-cyclopropyl-2-hydroxy-propyl)-amideHCID 71105623—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 7,7-dimethyl-5,6,7,8-tetrahydro-quinoline-2-carboxylic acid and (αR)-α-(aminomethyl)-α-methyl-cyclo-propanemethanol (CAN 912454-48-9) as starting materials, LC-MS (UV peak area/EIC) 99.3%, 303.2078 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321727B2
Source datasetuspto-grants-2016_04
ORD IDord-068c00cb88a14e5b86597d844e5f1b8b
Source noteuspto-grants-2016_04