L-(+)-Cysteine → (2-(4-(Dimethylamino)phenyl)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Participants

Role	Name	HCID	Charge
Reactant	L-(+)-Cysteine	HCID 5862	—
Reactant	4-(Dimethylamino)benzonitrile	HCID 70967	—
Reactant	4-(3,4,5-Trimethoxybenzoyl)-2-phenylthiazole	HCID 25227430	—
Product	(2-(4-(Dimethylamino)phenyl)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone	HCID 52949187	—

Reaction Steps

(2-(4-(Dimethylamino)phenyl)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (2o) was prepared using the same method as used of compound 1h from 4-(dimethylamino)benzonitrile and cysteine. 1H NMR (300 MHz, CDCl3) δ 8.12 (s, 1H), 7.88 (d, 2H), 7.80 (s, 2H), 6.73 (d, 2H), 3.96 (s, 3H), 3.95 (s, 6H), 3.05 (s, 6H); MS (ESI) m/z 421.1 (M+Na)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09447049B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-966102dc104d4baea22c7315b4793bc1
Source note	uspto-grants-2016_09