Leucinamide → HCID 71087391, compound

HRID 632262Notes

Reaction equation

HRID 632262 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([OH:20])=O)=[N:8][C:9]=2[O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH2:3][CH2:2]1.[NH2:21][C@@H:22]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:23]([NH2:25])=[O:24]>>[NH2:25][C:23](=[O:24])[C@@H:22]([NH:21][C:18](=[O:20])[C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:8]=1)[CH2:26][CH:27]([CH3:29])[CH3:28]

Participants

3

Reactant 2

HCID 69640LeucinamideHCID 710877855-Cyclopropyl-6-(pyridin-2-ylmethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 71087391HCID 71087391, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(pyridin-2-ylmethoxy)-pyridine-2-carboxylic acid (Example 189 b) and (2S)-2-amino-4-methyl-pentanamide (CAN 687-51-4) as starting materials, MS (EI): m/e=383.2 [M+H]+.

Sources & evidence

ORD record
ord-da4053c87ab4472fabc22499928c64b2
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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