3,3-Difluoroazetidine hydrochloride → 5-(3,3-Difluoroazetidin-1-yl)-N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6-((tetrahydrofuran-2-yl)methoxy)picolinamide

Participants

Role	Name	HCID	Charge
Reactant	3,3-Difluoroazetidine hydrochloride	HCID 2758247	—
Reactant	5-Bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide	HCID 71105644	—
Product	5-(3,3-Difluoroazetidin-1-yl)-N-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-6-((tetrahydrofuran-2-yl)methoxy)picolinamide	HCID 71088005	—

Reaction Steps

The title compound was synthesized by addition of 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7) to 5-bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide (Example 188) in analogy to the procedure described in Example 69 a, MS (EI): m/e=441.0 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09321727B2
Source dataset	uspto-grants-2016_04
ORD ID	ord-88bd203a6436466f8594b74b7ce7727e
Source note	uspto-grants-2016_04