Methyl 2-amino-2-ethylbutanoate → 2-(6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-2-ethylbutanoic acid

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Reaction Steps

The title compound can e.g. be synthesized by: i) coupling of 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) with 2-amino-2-ethyl-butyric acid methyl ester (CAN 70974-26-4) in analogy to Example 1; and ii) saponification of the ester group in analogy to the conditions described in Example 48 e), MS (EI): m/e=396.1 [M−H]−.

Provenance & Evidence