HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-amino-N,4,4-trimethyl-pentanamide → (S)-6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-amino-N,4,4-trimethyl-pentanamide | HCID 57635521 | — |
| Reactant | 6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid | HCID 71087292 | — |
| Product | (S)-6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)-N-(4,4-dimethyl-1-(methylamino)-1-oxopentan-2-yl)picolinamide | HCID 71087911 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and (2S)-2-amino-N,4,4-trimethyl-pentanamide (CAN 1160161-70-5) as starting materials, MS (EI): m/e=425.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321727B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-a710b0eca2f64194aa039b08ddd2a3f9 |
| Source note | uspto-grants-2016_04 |