2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amine → 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amide

HRID 632279Notes

Reaction equation

HRID 632279 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[F:21][C:22]([F:32])([F:31])[CH:23]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)[NH2:24]>>[F:32][C:22]([F:21])([F:31])[CH:23]([NH:24][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1

Participants

3

Reactant 2

HCID 252199112,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amineHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 711056556-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and 2,2,2-trifluoro-1-(pyridin-2-yl)ethanamine (CAN 503173-14-6) as starting materials, MS (EI): m/e=443.1 [M+H]+.

Sources & evidence

ORD record
ord-3f9daab8e7814f158330fdda79e937ce
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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