(2S)-2-amino-N,4,4-trimethyl-pentanamide → 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

HRID 632283Notes

Reaction equation

HRID 632283 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[C:15]([F:18])([F:17])[F:16])[CH2:3][CH2:2]1.[NH2:19][C@@H:20]([CH2:25][C:26]([CH3:29])([CH3:28])[CH3:27])[C:21]([NH:23][CH3:24])=[O:22]>>[CH3:27][C:26]([CH3:29])([CH3:28])[CH2:25][C@H:20]([NH:19][C:12]([C:10]1[CH:9]=[CH:8][C:7]([C:15]([F:18])([F:17])[F:16])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])[C:21](=[O:22])[NH:23][CH3:24]

Participants

3

Reactant 2

HCID 57635521(2S)-2-amino-N,4,4-trimethyl-pentanamideHCID 710874576-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid

Product 1

HCID 711056586-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (Example 113 d) and (2S)-2-amino-N,4,4-trimethyl-pentanamide (CAN 1160161-70-5) as starting materials, MS (EI): m/e=402.1 [M+H]+.

Sources & evidence

ORD record
ord-141f533603844351b9b60b214ee1e206
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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