HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid → 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid [cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid | HCID 71087457 | — |
| Reactant | (S)-2-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine | HCID 86674748 | — |
| Reactant | Cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methylamine | HCID 86674778 | — |
| Product | 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid [cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methyl]-amide | HCID 71105660 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (Example 113 d) and cyclopropyl-(5-methyl-[1,2,4]oxadiazol-3-yl)-methylamine (which can e.g. be prepared in a similar manner than (S)-2-cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (Example 38 e)) as starting materials, MS (EI): m/e=397.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321727B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-88ed89d6c98545d6aee4d6a674341162 |
| Source note | uspto-grants-2016_04 |