HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 5-bromo-6-(cyclopropylmethoxy)picolinate → 6-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 5-bromo-6-(cyclopropylmethoxy)picolinate | HCID 71087286 | — |
| Reactant | 6-Oxa-1-azaspiro[3.3]heptane oxalate | HCID 71303992 | — |
| Product | 6-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carboxylic acid methyl ester | HCID 71087484 | — |
Reaction Steps
The title compound was synthesized in analogy to the procedure described in Example 32 a), using 5-bromo-6-(cyclopropylmethoxy)-pyridine-2-carboxylic acid methyl ester (Example 9 d) and 6-oxa-1-azaspiro[3.3]heptane, oxalate salt (CAN 1359655-43-8) as starting materials. MS (EI): m/e=305.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321727B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-721af8dd044f448996a2a915dc991dce |
| Source note | uspto-grants-2016_04 |