Methylamine hydrochloride → HCID 71113180, compound

HRID 632311Notes

Reaction equation

[CH2:1]([C:3]([NH:9][C:10](=[O:29])[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[C:13]([O:21][CH2:22][CH:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:12]=1)([CH2:7][CH3:8])[C:4]([OH:6])=O)[CH3:2].Cl.[CH3:31][NH2:32]>>[CH2:1]([C:3]([NH:9][C:10]([C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[C:13]([O:21][CH2:22][CH:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:12]=1)=[O:29])([C:4](=[O:6])[NH:32][CH3:31])[CH2:7][CH3:8])[CH3:2]

Participants

Reactant 2

HCID 6364545Methylamine hydrochloride

HCID 71087372HCID 71087372, compound

Product 1

HCID 71113180HCID 71113180, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 2-ethyl-2-(6-((tetrahydro-2H-pyran-4-yl)methoxy)-5-(trifluoromethyl)picolinamido)butanoic acid and methanamine hydrochloride as starting materials. MS (EI): m/e=432.3 [M+H]+.

Sources & evidence

ORD record: ord-f71088f189ff41008baf4932f7303e33
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321727B2

Reaction notes

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