Tetrahydrofurfuryl alcohol → 6-((Tetrahydrofuran-2-yl)methoxy)-5-(trifluoromethyl)picolinic acid

HRID 632312Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[O:15]1[CH2:19][CH2:18][CH2:17][CH:16]1[CH2:20][OH:21]>>[O:15]1[CH2:19][CH2:18][CH2:17][CH:16]1[CH2:20][O:21][C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12]

Participants

Reactant 2

HCID 7360Tetrahydrofurfuryl alcohol

HCID 707010166-Chloro-5-(trifluoromethyl)picolinic acid

Product 1

HCID 710876466-((Tetrahydrofuran-2-yl)methoxy)-5-(trifluoromethyl)picolinic acid

Procedure

The title compound was prepared in analogy to the procedure described in Example 230 b), using 6-chloro-5-(trifluoromethyl)picolinic acid and (tetrahydrofuran-2-yl)methanol (CAN 97-99-4) as starting materials. MS: 290.0 [M−H]−.

Sources & evidence

ORD record: ord-5bbce5437c88488d9c1cf76246fcc60a
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321727B2

Reaction notes

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