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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 632318Generated: October 25, 2026

Methylamine hydrochloride → 6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

https://huagongshe.com/reaction/632318

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethylamine hydrochlorideHCID 6364545—
Reactant2-(6-(Cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoic acidHCID 71087462—
Product6-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amideHCID 71093527—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 2-(6-(cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoic acid and methanamine hydrochloride as starting materials. MS (EI): m/e=388.0 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09321727B2
Source datasetuspto-grants-2016_04
ORD IDord-bf0a36facefe4e6bba36c5cd546983c1
Source noteuspto-grants-2016_04