Leucine methyl ester hydrochloride → HCID 71087876, compound

HRID 632324Notes

Reaction equation

HRID 632324 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[CH3:19][O:20][C:21](=[O:28])[C@H:22]([CH2:24][CH:25]([CH3:27])[CH3:26])[NH2:23]>>[CH3:19][O:20][C:21](=[O:28])[C@@H:22]([NH:23][C:15]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[CH2:24][CH:25]([CH3:27])[CH3:26]

Participants

3

Reactant 2

HCID 2723695Leucine methyl ester hydrochlorideHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 71087876HCID 71087876, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and L-leucine methyl ester hydrochloride (1:1) (CAN 7517-19-3) as starting materials, LC-MS (UV peak area/ESI) 100%, 361.2120 (M+H)+.

Sources & evidence

ORD record
ord-8a8bfa6770e64a249aa3e60d9440b47a
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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