Azetidine → 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid [1-(azetidine-1-carbonyl)-1-ethyl-propyl]-amide

HRID 632328Notes

Reaction equation

HRID 632328 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([NH:17][C:18]([CH2:24][CH3:25])([CH2:22][CH3:23])[C:19](O)=[O:20])=[O:16])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH:26]1[CH2:29][CH2:28][CH2:27]1>>[N:26]1([C:19]([C:18]([NH:17][C:15]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]3[CH2:3][CH2:2]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:16])([CH2:22][CH3:23])[CH2:24][CH3:25])=[O:20])[CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 10422AzetidineHCID 710875422-(5-Cyclopropyl-6-(cyclopropylmethoxy)picolinamido)-2-ethylbutanoic acid

Product 1

HCID 710935665-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid [1-(azetidine-1-carbonyl)-1-ethyl-propyl]-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 2-(5-cyclopropyl-6-(cyclopropylmethoxy)picolinamido)-2-ethylbutanoic acid and azetidine (CAN 503-29-7) as starting materials. MS (EI): m/e=386.0 [M+H]+.

Sources & evidence

ORD record
ord-1790fdc8b05a4f3680f897cd2c9c9d01
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

Loading…