2-(2-Pyridyl)-2-propylamine → 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-methyl-1-pyridin-2-yl-ethyl)-amide
Reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[CH3:18][C:19]([CH3:27])([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[NH2:20]>>[CH3:18][C:19]([NH:20][C:15]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[CH3:27]Participants
3
Procedure
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and α,α-dimethyl-2-pyridinemethanamine (CAN 52568-28-2) as starting materials, LC-MS (UV peak area/ESI) 100%, 352.2021 (M+H)+.
Sources & evidence
- ORD record
- ord-2482e88991b248359af81c396bed592a
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09321727B2
Reaction notes
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