(2S)-2-amino-N,4,4-trimethyl-pentanamide → 6-(4-Fluoro-benzyl)-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

HRID 632345Notes

Reaction equation

HRID 632345 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][C:7]2[N:12]=[C:11]([C:13]([OH:15])=O)[CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH2:18][C@@H:19]([CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])[C:20]([NH:22][CH3:23])=[O:21]>>[CH3:26][C:25]([CH3:28])([CH3:27])[CH2:24][C@H:19]([NH:18][C:13]([C:11]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:17][CH:16]=2)[N:12]=1)=[O:15])[C:20](=[O:21])[NH:22][CH3:23]

Participants

3

Reactant 2

HCID 57635521(2S)-2-amino-N,4,4-trimethyl-pentanamideHCID 710874636-(4-Fluorobenzyl)picolinic acid

Product 1

HCID 711056926-(4-Fluoro-benzyl)-pyridine-2-carboxylic acid ((S)-3,3-dimethyl-1-methylcarbamoyl-butyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(4-fluorobenzyl)picolinic acid (Example 277 a) and (2S)-2-amino-N,4,4-trimethyl-pentanamide (CAN 1160161-70-5) as starting materials. MS (EI): m/e=372.0 [M+H]+.

Sources & evidence

ORD record
ord-c0061b96d5a7422ba444468441429064
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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