3-Thiophenamine, tetrahydro-, 1,1-dioxide → 6-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (1,1-dioxo-tetrahydro-1lambda6-thiophen-3-yl)-amide

HRID 632352Notes

Reaction equation

HRID 632352 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[O:21]=[S:22]1(=[O:28])[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23]1>>[O:21]=[S:22]1(=[O:28])[CH2:26][CH2:25][CH:24]([NH:27][C:12]([C:10]2[CH:9]=[CH:8][C:7]([N:15]3[CH2:18][C:17]([F:20])([F:19])[CH2:16]3)=[C:6]([O:5][CH2:4][CH:1]3[CH2:2][CH2:3]3)[N:11]=2)=[O:14])[CH2:23]1

Participants

3

Reactant 2

HCID 228073-Thiophenamine, tetrahydro-, 1,1-dioxideHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 711056916-Cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (1,1-dioxo-tetrahydro-1lambda6-thiophen-3-yl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and 1,1-dioxidotetrahydrothien-3-ylamine (CAN 6338-70-1) as starting materials. MS (EI): m/e=402.1 [M+H]+.

Sources & evidence

ORD record
ord-46f9449a4da04a56bf326302a2d410fb
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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