HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-ethyl-N-methyl-butyramide → 6-(2,2,3,3,3-Pentafluoro-propoxy)-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-ethyl-N-methyl-butyramide | HCID 79810370 | — |
| Reactant | 6-(2,2,3,3,3-Pentafluoro-propoxy)-pyridine-2-carboxylic acid | HCID 86674786 | — |
| Reactant | 5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid | HCID 86674787 | — |
| Product | 6-(2,2,3,3,3-Pentafluoro-propoxy)-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide | HCID 71491292 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using the mixture of 6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid and 5-cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid (Example 297b) and 2-amino-2-ethyl-N-methyl-butyramide (Example 70b) as starting materials, the product was isolated by preparative HPLC; LC-MS (UV peak area/ESI) 100%, 398.1488 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321727B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-440938c2dc54447da4656daff9314a2a |
| Source note | uspto-grants-2016_04 |