5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → HCID 71093523, compound

HRID 632372Notes

Reaction equation

HRID 632372 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C:20]([C:23]1[O:27][N:26]=[C:25]([NH2:28])[N:24]=1)([CH3:22])[CH3:21]>>[NH2:28][C:25]1[N:24]=[C:23]([C:20]([NH:19][C:15]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]3[CH2:2][CH2:3]3)=[C:9]([O:10][CH2:11][CH:12]3[CH2:13][CH2:14]3)[N:8]=2)=[O:17])([CH3:22])[CH3:21])[O:27][N:26]=1

Participants

3

Reactant 2

HCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 86674792HCID 86674792, compound

Product 1

HCID 71093523HCID 71093523, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and 5-(1-amino-1-methyl-ethyl)-[1,2,4]oxadiazol-3-ylamine hydrochloride (1:1) (Example 309 b) as starting materials, LC-MS (UV peak area/ESI) 100%, 358.1872 (M+H)+.

Sources & evidence

ORD record
ord-246f4a9d69fb4370921744ab065f1eef
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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