化工社化工社 化学情報印刷レポート · 研究参考用
L-Leucine, ethyl ester, hydrochloride (1:1) → (S)-Ethyl 2-(6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-4-methylpentanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Leucine, ethyl ester, hydrochloride (1:1) | HCID 11658447 | — |
| 反応物 | 6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid | HCID 71087292 | — |
| 生成物 | (S)-Ethyl 2-(6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinamido)-4-methylpentanoate | HCID 71105697 | — |
反応手順
The title compound was synthesized in analogy to Example 1, using 6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid (Example 69 b) and (S)-ethyl 2-amino-4-methylpentanoate hydrochloride (CAN 2743-40-0) as starting materials. MS (EI): m/e=426.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09321727B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-fbc0985fc5b94785826fa0f6699107cb |
| 出典メモ | uspto-grants-2016_04 |