5-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid → HCID 71105709, compound

HRID 632396Notes

Reaction equation

HRID 632396 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([OH:20])=O)=[N:8][C:9]=2[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.Cl.[NH2:22][C@@H:23]([CH2:27][CH:28]1[CH2:30][CH2:29]1)[C:24]([NH2:26])=[O:25]>>[C:24]([C@@H:23]([NH:22][C:18]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)[N:8]=1)=[O:20])[CH2:27][CH:28]1[CH2:30][CH2:29]1)(=[O:25])[NH2:26]

Participants

3

Reactant 2

HCID 710876985-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acidHCID 86674760HCID 86674760, compound

Product 1

HCID 71105709HCID 71105709, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid (Example 155 g) and (S)-2-amino-3-cyclopropylpropanamide hydrochloride (Example 97 a) as starting materials. MS (EI): m/e=382.1 [M+H]+.

Sources & evidence

ORD record
ord-a65e20c8585b499c9e7d25bd8ba52ab9
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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