関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 6-(Isobutylsulfonyl)picolinonitrile | HCID 71087471 | — |
| 生成物 | 6-(Isobutylsulfonyl)picolinic acid | HCID 71087249 | 85% |
反応手順
A suspension of 6-(isobutylsulfonyl)picolinonitrile (126 mg, 562 μmol) and powdered sodium hydroxide (89.9 mg, 2.25 mmol) in water (15 mL) was heated to 90° C. for 24 h, poured into ice water/0.1 N aqueous HCl solution (1:1) and extracted 3 times with EtOAc. The organic layers were washed with ice water/brine (1:1), dried over Na2SO4 and concentrated in vacuo to give the title compound (116 mg, 85%) as white solid which was sufficiently pure to be used in the next reaction step. MS (EI): m/e=241.9 [M−H]−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09321727B2 |
|---|
| 出典データセット | uspto-grants-2016_04 |
|---|
| ORD ID | ord-8d21d0c342e64dcf858e44ddb5f1fdcf |
|---|
| 出典メモ | uspto-grants-2016_04 |
|---|
