HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-amino-2-ethylbutanoate hydrochloride → Ethyl 2-(5-cyclopropyl-6-((tetrahydro-2H-pyran-4-yl)methoxy)picolinamido)-2-ethylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-amino-2-ethylbutanoate hydrochloride | HCID 24201639 | — |
| Reactant | 5-Cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid | HCID 71087254 | — |
| Reactant | 5-Cyclopropyl-6-(tetrahydro-pyran-4-ylmethoxy)-pyridine-2-carboxylic acid | HCID 71087560 | — |
| Product | Ethyl 2-(5-cyclopropyl-6-((tetrahydro-2H-pyran-4-yl)methoxy)picolinamido)-2-ethylbutanoate | HCID 71087540 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(tetrahydro-pyran-4-ylmethoxy)-pyridine-2-carboxylic acid (which can e.g. be prepared in a similar manner than 5-cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid (Example 166 b)) and ethyl 2-amino-2-ethylbutanoate hydrochloride (CAN 1135219-29-2) as starting materials. MS (EI): m/e=419.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321727B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-d3e52d35320544a99f1afcdc5d779052 |
| Source note | uspto-grants-2016_04 |