(2S)-2-Amino-N,3,3-trimethylbutanamide → 5-Cyclopropyl-6-(2-methyl-propane-1-sulfonyl)-pyridine-2-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

HRID 632443Notes

Reaction equation

HRID 632443 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([OH:19])=O)=[N:8][C:9]=2[S:10]([CH2:13][CH:14]([CH3:16])[CH3:15])(=[O:12])=[O:11])[CH2:3][CH2:2]1.[NH2:20][C@@H:21]([C:26]([CH3:29])([CH3:28])[CH3:27])[C:22]([NH:24][CH3:25])=[O:23]>>[CH3:27][C:26]([CH3:29])([CH3:28])[C@H:21]([NH:20][C:17]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([S:10]([CH2:13][CH:14]([CH3:15])[CH3:16])(=[O:11])=[O:12])[N:8]=1)=[O:19])[C:22](=[O:23])[NH:24][CH3:25]

Participants

3

Reactant 2

HCID 445856(2S)-2-Amino-N,3,3-trimethylbutanamideHCID 710877315-Cyclopropyl-6-(isobutylsulfonyl)picolinic acid

Product 1

HCID 866748015-Cyclopropyl-6-(2-methyl-propane-1-sulfonyl)-pyridine-2-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(isobutylsulfonyl)picolinic acid (Example 351 b) and (2S)-2-amino-N,3,3-trimethyl-butanamide (CAN 89226-12-0) as starting materials. MS (EI): m/e=410.6 [M+H]+.

Sources & evidence

ORD record
ord-2d50843937c34ff2aa439c9e1c7b84e3
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

Loading…