HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 78010199, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | HCID 61310151 | HCID 61310151 | — |
| Reactant | 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 71087346 | — |
| Solvent | Heptane | HCID 8900 | — |
| Product | HCID 78010199 | HCID 78010199 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and α-amino-cyclopropaneacetamide (CAN 1100749-41-4) as starting materials. The product was isolated by chiral chromatography on Chiralpak AD using heptane/20% 2-propanol as eluent. The (+)-enantiomer was isolated. LC-MS (UV peak area/ESI) 97.7%, 330.1804 (M+H)+, αD20 (MeOH)=+43.3°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321727B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-c1e69c74c2174379b706b7f52a5f7f82 |
| Source note | uspto-grants-2016_04 |