Hydrogen Bromide → (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-(1-{5-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]pyrimidin-2-yl}piperidin-4-yl)-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol dihydrobromide

Participants

Reaction Conditions

Reaction Steps

To a solution of 50.7 mg (0.0675 mmol) of (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-(1-{5-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]pyrimidin-2-yl}piperidin-4-yl)-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 19, in 0.5 ml of methyl ethyl ketone, 15 μl (0.13 mmol) of 47% hydrobromic acid was added dropwise with stirring at 40° C. Then, the reaction mixture was cooled to 20° C. and stirred for 30 minutes. The precipitated solid was obtained by filtration, washed with methyl ethyl ketone and then dried under reduced pressure at 60° C. to provide 57 mg of the title compound as a white powder (yield: 93%).

Provenance & Evidence