Hydrochloric Acid → (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-(1-{5-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]pyrimidin-2-yl}piperidin-4-yl)-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol dihydrochloride

Participants

Reaction Steps

Reactions similar to those of Example 3 were performed except for using 12 μl (0.14 mmol) of 35% hydrochloric acid instead of 47% hydrobromic acid and using a mixed solution of 0.5 ml of ethyl acetate and 35 μl of ethanol instead of methyl ethyl ketone, and from 51.2 mg (0.0682 mmol) of (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-(1-{5-[3-hydroxy-2-(hydroxymethyl)-2-methylpropoxy]pyrimidin-2-yl}piperidin-4-yl)-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 19, 43 mg of the title compound was obtained as a white powder (yield: 77%).

Provenance & Evidence