Hydrochloric Acid → HCID 71656880, compound

Participants

Reaction Steps

To a solution of 48.6 mg (0.066 mmol) of (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-{1-[5-(3-hydroxy-3-methylbutoxy)pyrimidin-2-yl]piperidin-4-yl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 16, in 0.1 ml of acetone, 0.0058 ml (0.067 mmol) of 35% hydrochloric acid was added at room temperature. Subsequently, a small amount of a seed crystal was added thereto, and the reaction mixture was stirred for 50 minutes. The precipitated solid was obtained by filtration, washed with 0.1 ml of acetone five times and then dried under reduced pressure at 40° C. to provide 26.4 mg of the title compound as a white powder (yield: 52%).

Provenance & Evidence