Hydrochloric Acid → HCID 71656880, compound

Participants

Reaction Steps

To a solution of 270 mg (0.367 mmol) of (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-{1-[5-(3-hydroxy-3-methylbutoxy)pyrimidin-2-yl]piperidin-4-yl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 16, in 0.54 ml of acetone, 0.0322 ml (0.386 mmol) of 35% hydrochloric acid was added at room temperature, and the mixture was stirred. This solution was left standing overnight at −20° C. After precipitation of a solid, the reaction solution was further stirred at room temperature for 1 hour. The solid was obtained by filtration, washed with a 1:1 mixed solvent of acetone and tert-butyl methyl ether and then dried under reduced pressure at 40° C. to provide 179 mg of the title compound as a white powder (yield: 63%).

Provenance & Evidence