Hydrogen Bromide → HCID 71656882, compound

Participants

Reaction Steps

To a solution of 50.0 mg (0.068 mmol) of (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-{1-[5-(3-hydroxy-3-methylbutoxy)pyrimidin-2-yl]piperidin-4-yl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 16, in 0.1 ml of acetone, 0.008 ml (0.069 mmol) of 47% hydrobromic acid was added at room temperature. Subsequently, a small amount of a seed crystal was added thereto, and the reaction mixture was stirred for 50 minutes. The precipitated solid was obtained by filtration, washed with 0.1 ml of acetone five times and then dried under reduced pressure at 40° C. to provide 38.1 mg of the title compound as a white powder (yield: 69%).

Provenance & Evidence