Hydrogen Bromide → HCID 71656882, compound

Participants

Reaction Steps

Reactions similar to those of Example 6-2 were performed except for using 0.0308 ml (0.271 mmol) of 47% hydrobromic acid instead of 35% hydrochloric acid and using 0.38 ml of acetone, and from 190 mg (0.259 mmol) of (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-{1-[5-(3-hydroxy-3-methylbutoxy)pyrimidin-2-yl]piperidin-4-yl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 16, 136 mg of the title compound was obtained as a white powder (yield: 64%).

Provenance & Evidence