Benzenesulfonic Acid → HCID 131735435, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 30.0 mg (0.0408 mmol) of (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-2-{1-[5-(3-hydroxy-3-methylbutoxy)pyrimidin-2-yl]piperidin-4-yl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 16, in 0.4 ml of tert-butyl methyl ether, 0.013 ml (0.041 mmol) of 3.16 M benzenesulfonic acid aqueous solution was added dropwise with stirring at 40° C. Then, the reaction mixture was cooled to room temperature and stirred for 30 minutes. The precipitated solid was obtained by filtration, washed with tert-butyl methyl ether and then dried under reduced pressure at 60° C. to provide 29.8 mg of the title compound as a white powder (yield: 82%).

Provenance & Evidence