反应详情

温度

45 °C

To a solution of 36.2 mg (50.1 μmol) of (5S)-4-(4,4-Difluorocyclohexyl)-2-[1-(5-{[(2S)-2,3-dihydroxypropyl]oxy}pyrimidin-2-yl)piperidin-4-yl]-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 25, in 0.36 ml of acetone, 9.2 μl (110 μmol) of 35% hydrochloric acid was added dropwise with stirring at 45° C., and the mixture was stirred for 10 minutes. Then, stirring was continued at room temperature for 30 minutes, and the precipitated solid was obtained by filtration, washed with acetone and then dried under reduced pressure at 40° C. to provide 26.3 mg of the title compound as a white powder (yield: 66%).

1. stirringthe mixture was stirred for 10 minutes
2. stirringThen, stirring
3. customthe precipitated solid was obtained by filtration
4. washwashed with acetone
5. customdried under reduced pressure at 40° C.