Acetone → (5S)-4-(4,4-Difluorocyclohexyl)-2-[1-(5-{[(2R)-2,3-dihydroxypropyl]oxy}pyrimidin-2-yl)piperidin-4-yl]-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol dihydrochloride

Participants

Reaction Steps

Reactions similar to those of Example 13 were performed except for using 10.8 μl (130 μmol) of 35% hydrochloric acid and using a mixed solvent of 0.43 ml of acetone and 0.43 ml of tert-butyl methyl ether instead of acetone, and from 43.3 mg (59.9 μmol) of (5S)-4-(4,4-Difluorocyclohexyl)-2-[1-(5-{[(2R)-2,3-dihydroxypropyl]oxy}pyrimidin-2-yl)piperidin-4-yl]-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 27, 24.0 mg of the title compound was obtained as a white powder (yield: 50%).

Provenance & Evidence