Acetone → (5S)-4-(4,4-Difluorocyclohexyl)-2-[1-(5-{[(2R)-2,3-dihydroxypropyl]oxy}pyrimidin-2-yl)piperidin-4-yl]-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol dihydrobromide

Participants

Reaction Steps

Reactions similar to those of Example 13 were performed except for using 17.3 μl (152 μmol) of 47% hydrobromic acid instead of 35% hydrochloric acid and using 0.50 ml of a 1:1 mixed solvent of acetone and tert-butyl methyl ether instead of acetone, and from 49.5 mg (68.5 μmol) of (5S)-4-(4,4-Difluorocyclohexyl)-2-[1-(5-{[(2R)-2,3-dihydroxypropyl]oxy}pyrimidin-2-yl)piperidin-4-yl]-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 27, 36.6 mg of the title compound was obtained as a white powder (yield: 60%).

Provenance & Evidence