Methanesulfonic Acid → (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-2-(1-{5-[3-(methylsulfonyl)propoxy]pyrimidin-2-yl}piperidin-4-yl)-5,6,7,8-tetrahydroquinolin-5-ol methanesulfonate

Participants

Reaction Steps

Reactions similar to those of Example 13 were performed except for using 3.8 μl (57 μmol) of methanesulfonic acid instead of 35% hydrochloric acid and using 1.5 ml of isopropyl acetate instead of acetone, and from 40.0 mg (52.0 μmol) of (5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-2-(1-{5-[3-(methylsulfonyl)propoxy]pyrimidin-2-yl}piperidin-4-yl)-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 28, 35.3 mg of the title compound was obtained as a white powder (yield: 78%).

Provenance & Evidence