Hydrogen Bromide → HCID 117687878, compound

Participants

Reaction Steps

Reactions similar to those of Example 13 were performed except for using 15.2 μl (134 μmol) of 47% hydrobromic acid instead of 35% hydrochloric acid and using 0.45 ml of acetone, and from 45.7 mg (60.7 μmol) of (5S)-2-{1-[5-(3-Carboxyphenyl)pyrimidin-2-yl]piperidin-4-yl}-4-(4,4-difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-5-ol, which was prepared by a method similar to that of Reference Example 30, 27.2 mg of the title compound was obtained as a white powder (yield: 49%).

Provenance & Evidence