反应详情

温度

80 °C

To a solution of 453 mg (0.589 mmol) of 2-[4-((5S)-4-(4,4-Difluorocyclohexyl)-3-{(S)-fluoro[4-(trifluoromethyl)phenyl]methyl}-5-[(4-methoxybenzyl)oxy]-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-2-yl)piperidin-1-yl]pyrimidin-5-ol, which was prepared by a method similar to that of Reference Example 14, in 5 ml of 1,4-dioxane, 1 ml of 6 N hydrochloric acid was added, and the mixture was stirred at 80° C. for 4.5 hours. After completion of the reaction, the reaction solution was poured into saturated sodium hydrogencarbonate aqueous solution and extracted with ethyl acetate. The obtained organic phases were combined and washed with saturated sodium chloride aqueous solution, and then the solvent was distilled off under reduced pressure. The obtained residue was subjected to silica gel column chromatography [n-hexane/ethyl acetate=76/24-40/60 (V/V)] and the fraction including the desired compound was concentrated under reduced pressure to provide 360 mg of the title compound as a white solid (yield: 94%).

1. customAfter completion of the reaction
2. extractionextracted with ethyl acetate
3. washwashed with saturated sodium chloride aqueous solution
4. distillationthe solvent was distilled off under reduced pressure
5. concentrationwas concentrated under reduced pressure