HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 58497086, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 21828432 | HCID 21828432 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 58497086 | HCID 58497086 | — |
Reaction Steps
Formamidine acetate was reacted with diethyl-ethylmalonate in the presence of sodium ethoxide in dry ethanol to yield 5-ethylpyrimidine-4,6-diol, which was converted to 4,6-Dichloro-5-ethylpyrimidine by POCl3 in the presence of TEA in toluene. 4,6-Dichloro-5-ethylpyrimidine was then reacted with aqueous ammonia in n-butanol at 100° C. to afford 4-amino-5-ethyl-6-chloropyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321760B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-fefd416154464c70b09f21a099e8ecd4 |
| Source note | uspto-grants-2016_04 |