1-(4-Chloro-2-hydroxyphenyl)ethanone → HCID 89442557, compound

HRID 632724Notes

Reaction equation

HRID 632724 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([NH2:20])=[N:10][CH:11]=[N:12][C:13]=2[N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:4][CH:3]=1.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](=O)[CH3:29])=[C:24]([OH:31])[CH:23]=1>>[NH2:20][C:9]1[N:10]=[CH:11][N:12]=[C:13]([N:14]2[CH2:19][CH2:18][N:17]([CH:28]([C:25]3[CH:26]=[CH:27][C:22]([Cl:21])=[CH:23][C:24]=3[OH:31])[CH3:29])[CH2:16][CH2:15]2)[C:8]=1[C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 10515131-(4-Chloro-2-hydroxyphenyl)ethanoneHCID 89442443HCID 89442443, compound

Product 1

HCID 89442557HCID 89442557, compound

Procedure

The title compound was prepared in an analogous manner as Example (60) by 5-(4-fluorophenyl)-6-(piperazin-1-yl)pyrimidin-4-amine reacted with 1-(4-chloro-2-hydroxyphenyl)ethanone. LC-MS: (M+1=428, obsd.=428/430).

Sources & evidence

ORD record
ord-c0fc15c18f844ae5bb9698f2b510648d
Source dataset
uspto-grants-2016_04
Patent number
US09321760B2

Reaction notes

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